Related Experiment Video

Updated: Feb 25, 2026

Non-Invasive Endotracheal Administration of Lipopolysaccharide to Induce Acute Lung Injury in Rodents
04:14

Non-Invasive Endotracheal Administration of Lipopolysaccharide to Induce Acute Lung Injury in Rodents

Published on: December 5, 2025

233

The emerging role of transient receptor potential channels in chronic lung disease

Maria G Belvisi1, Mark A Birrell2

  • 1Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK m.belvisi@imperial.ac.uk.

The European Respiratory Journal
|August 5, 2017
PubMed

Insights

New therapeutic targets are needed for chronic lung diseases like asthma and COPD. Transient receptor potential ion channels show promise for treating these conditions due to their role in lung inflammation and symptoms.

Area of Science:

  • Pulmonary Medicine
  • Molecular Pharmacology

Background:

  • Chronic lung diseases, including asthma, COPD, and idiopathic pulmonary fibrosis, represent a significant global health challenge with limited effective treatments.
  • Current drug discovery for these conditions has yielded disappointing results, highlighting the urgent need for novel therapeutic targets.

Purpose of the Study:

  • To explore the potential of Transient Receptor Potential (TRP) ion channels as novel therapeutic targets for chronic lung diseases.
  • To investigate the role of TRP channels in the pathophysiology of respiratory diseases.

Main Methods:

  • Review of existing literature on TRP channel expression and function in lung tissue.
  • Analysis of the involvement of TRP channels in inflammatory and structural changes associated with chronic lung diseases.
  • Examination of TRP channel contribution to respiratory symptoms like bronchospasm and cough.

Main Results:

  • TRP ion channels are widely expressed throughout the lung.
  • These channels play a crucial role in modulating lung inflammation and structural remodeling.
  • TRP channels are implicated in the generation of key respiratory symptoms observed in chronic lung diseases.

Conclusions:

  • Transient Receptor Potential ion channels represent a promising new class of therapeutic targets for chronic lung diseases.
  • Targeting TRP channels could offer novel treatment strategies for conditions such as asthma, COPD, and idiopathic pulmonary fibrosis.
  • Further research into TRP channel modulation is warranted to develop effective therapies for unmet needs in respiratory medicine.

More Related Videos

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

1.4K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.2K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.9K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.2K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.9K