COMPARISON OF INTRACERVICAL PROSTAGLANDIN E2 AND INTRAVENOUS OXYTOCIN IN INDUCTION OF LABOUR.

Area of Science:

• Obstetrics and Gynecology
• Reproductive Medicine

Background:

• Induction of labor is a common obstetric procedure.
• An unfavorable cervix presents a challenge for successful labor induction.
• Comparing induction methods is crucial for optimizing patient outcomes.

Purpose of the Study:

• To compare the efficacy of intracervical Prostaglandin E2 gel versus Oxytocin for labor induction in patients with an unfavorable cervix.
• To evaluate the impact on cervical score, time to labor establishment, and Cesarean section rates.

Main Methods:

• A comparative study involving 154 patients with unfavorable cervices.
• Group 1: 76 patients received a single intracervical dose of 0.5 mg Prostaglandin E2 gel.
• Group 2: 78 patients received Oxytocin induction.

Main Results:

• Labor was established within 24 hours in 71.4% of primigravidas and 91.7% of multigravidas in the Prostaglandin E2 group, versus 65.6% and 89.1% in the Oxytocin group.
• Significant improvement in cervical score observed 12 hours post-Prostaglandin E2 application.
• Reduced Cesarean section rates noted in the Prostaglandin E2 group.

Conclusions:

• Intracervical Prostaglandin E2 gel is an effective method for labor induction in women with unfavorable cervices.
• Prostaglandin E2 gel offers advantages over Oxytocin, including improved cervical ripening and a lower Cesarean section rate.
• The treatment demonstrated a favorable safety profile for both mother and neonate.