Related Experiment Video
Updated: Feb 25, 2026
04:22
Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
1.1K
SILDENAFIL-ORAL MEDICATION FOR ERECTILE DYSFUNCTION-A REVIEW
1Classified Specialist Surgery and Urologist, Department of Urology, Army Hospital (Referral & Research), Delhi Cantt, Delhi- 110010.
Medical Journal, Armed Forces India
|August 5, 2017
Summary
Sildenafil, a phosphodiesterase type V inhibitor, offers a revolutionary oral treatment for erectile dysfunction by enhancing cyclic guanosine monophosphate levels. Further research is needed to fully understand its efficacy, safety, and potential for misuse.
Area of Science:
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) is increasingly recognized and treated.
- Traditional ED treatments included intracavernosal injections and penile prosthesis implantation.
Purpose of the Study:
- To introduce Sildenafil as a novel oral treatment for erectile dysfunction.
- To discuss the mechanism of action and potential benefits of Sildenafil.
Main Methods:
- Review of Sildenafil's pharmacological properties.
- Analysis of its role in treating erectile dysfunction.
Main Results:
- Sildenafil selectively inhibits phosphodiesterase type V.
- This inhibition increases cyclic guanosine monophosphate (cGMP) in the corpora cavernosa, enhancing erection upon sexual stimulation.
- Sildenafil represents a significant advancement in ED treatment.
Conclusions:
- Sildenafil has revolutionized erectile dysfunction management.
- While promising with a favorable side effect profile, further investigation into its efficacy, safety, misuse, and overuse is warranted.
Related Concept Videos
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
653
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
653
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
312
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
312
01:20Disorders of the Male Reproductive System
5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
01:17Male Sexual Response: Erection & Ejaculation
23.2K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
23.2K
01:16Antianginal Drugs: Nitrates and β-Blockers
1.7K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.7K
01:23Antihypertensive Drugs: Vasodilators
2.3K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.3K