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Clinical studies on progressive retinal atrophy in 31 dogs
D N Kelawala1, D B Patil2, P V Parikh2
1Ph.D. Scholar in Veterinary Surgery and Radiology, Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat-388001, India.
Iranian Journal of Veterinary Research
|August 5, 2017
Summary
This study investigated hereditary retinal degeneration in Indian dogs, primarily progressive retinal atrophy (PRA). Findings revealed significant ophthalmoscopic changes and non-recordable electroretinograms (ERG) in affected dogs, confirming generalized photoreceptor disease.
Area of Science:
- Veterinary Ophthalmology
- Canine Genetics
- Retinal Diseases
Background:
- Hereditary retinal degenerations are a concern in canine populations.
- Progressive retinal atrophy (PRA) is a common form, leading to vision loss.
- Limited data exists on PRA in dog breeds originating from India.
Purpose of the Study:
- To characterize hereditary retinal degeneration in dogs bred in India.
- To identify clinical and electroretinographic findings in suspected progressive retinal atrophy (PRA) cases.
- To provide insights into the prevalence and breed distribution of PRA in this population.
Main Methods:
- Conducted a 2-year observational study on 31 dogs with suspected PRA.
- Performed comprehensive ophthalmologic examinations, including Schirmer's tear test, fluorescein staining, tonometry, slit lamp biomicroscopy, and ocular ultrasound.
- Utilized ophthalmoscopy, fundoscopy, and electroretinography (ERG) to assess retinal function and structure.
Main Results:
- Progressive retinal atrophy (PRA) was suspected in 31 dogs, with onset typically involving nyctalopia and hemeralopia.
- Spitz dogs were the most affected breed (58%).
- Ophthalmoscopy revealed tapetal hyperreflectivity, attenuated retinal vessels, depigmentation, and optic disc atrophy. ERG showed non-recordable responses, indicating generalized photoreceptor dysfunction.
Conclusions:
- The study identified hereditary retinal degeneration, likely progressive retinal atrophy (PRA), in Indian dog breeds.
- Clinical signs and ERG findings confirm a severe, generalized photoreceptor disease.
- Further genetic research is warranted to understand the specific mutations and inheritance patterns in affected Indian dog populations.
