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Redox Imbalance in the Development of Colorectal Cancer

Hao Liu1, Xin Liu1, Chundong Zhang1

  • 1Department of Biochemistry and Molecular Biology, and Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P. R. China.

Journal of Cancer
|August 5, 2017
PubMed

Insights

Redox imbalance, an imbalance between oxidants and antioxidants, significantly impacts cell function. This overview explores the connection between this imbalance and colorectal cancer (CRC).

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Redox imbalance arises from disrupted oxidant-antioxidant equilibrium.
  • Reactive oxygen species (ROS) are key oxidants involved in cellular signaling and damage.
  • Elevated ROS levels can be cytotoxic and lead to macromolecule oxidation, particularly proteins.

Purpose of the Study:

  • To provide an overview of the relationship between redox imbalance and colorectal cancer (CRC).
  • To highlight the mechanisms through which ROS affect cellular processes in the context of CRC.

Main Methods:

  • Literature review and synthesis of existing research on redox biology and CRC.
  • Analysis of the role of ROS in cellular signaling, damage, and disease pathogenesis.

Main Results:

  • ROS play dual roles: essential for cell survival at low concentrations and cytotoxic at high concentrations.
  • Oxidative modification of proteins by ROS is implicated in various biological processes, including CRC development.
  • Disruption of the redox balance is a critical factor in CRC pathogenesis.

Conclusions:

  • Redox imbalance is intricately linked to the development and progression of colorectal cancer.
  • Understanding the crosstalk between redox status and CRC is crucial for potential therapeutic strategies.
  • Further research into ROS-mediated pathways in CRC is warranted.
Keywords:
CRCcysteine residues.oxidative stressredox modification

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