The failure of long term effect of cyclophosphamide on systemic immunologic connective tissue disease in rabbit

Cyclophosphamide is given intravenously in the high dose of 12 mg/kg/day during 2 months from the beginning of immunological systemic connective tissue disease in rabbits, according to the modified Glynn's model. The effects of this alkylating drug are studied after the termination of treatment. At short term (15 days), cyclophosphamide depresses the inflammation of synovia in stimulated and non-stimulated joints, the humoral and cellular immunities, but the drug does not modify the other systemic lesions. At long term (between 1 and 6 months), these effects of cyclophosphamide disappear completely.