Controlled Zn²⁺-Triggered Drug Release by Preferred Coordination of Open Active Sites within Functionalization Indium...

Drug delivery in target regions could make extraordinary progress in chemoselective therapies. A novel preferred coordination (PC) strategy referring to proactive interacting with open active sites to replace previous occupation by ion-exchange for controlling release of drug molecules is well-constructed. Two topological types of MOF-In1 (Schläfli symbol: (4,8)-connected of (4¹⁰·6¹⁵·8³)(4⁵·6)₂) and MOF-In2 (Schläfli symbol: (4,4)-connected of (6⁶)) show the specific way. Increasing node connectivity as well as the trapping of guest OH^- anions, 5-fluorouracil (5-FU) is preferentially captured into the MOF-In1, which exhibits an outstanding loading capacity around 34.32 wt %. ¹⁹F NMR spectroscopy was further employed to investigate host-guest interaction and reveal the binding constant (K_a = 3.84 × 10² M^-1). Meanwhile, the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution by biofriendly Zn²⁺-triggered is realized. With an elevated Zn²⁺ concentration, the drug release will be enhanced. This efficient strategy for MOFs as multifunctional drug carrier opens a new avenue for biological and medical applications.