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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Feb 25, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Making Basic Science Studies in Glaucoma More Clinically Relevant: The Need for a Consensus.

Carol B Toris1, Claire Gelfman2, Andy Whitlock2

  • 11 Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio.

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Developing integrated research maps and consensus statements is crucial for advancing glaucoma therapy. This includes evaluating preclinical tools and animal models, especially for normal-tension glaucoma, to accelerate clinical impact.

Keywords:
basic scienceconsensus statementglaucomatranslational research

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Translational Research

Background:

  • Glaucoma is a progressive optic neuropathy causing irreversible vision loss.
  • Current understanding of glaucoma's pathophysiology is incomplete, hindering effective treatment development.
  • Researchers face challenges due to a lack of integrated research pathways and consensus guidelines.

Purpose of the Study:

  • To advocate for the creation of integrated "bench-to-bedside" research maps for glaucoma.
  • To emphasize the need for consensus statements to guide glaucoma research questions, techniques, and models.
  • To highlight the importance of evaluating preclinical research tools and animal models.

Main Methods:

  • Reviewing existing literature on glaucoma pathophysiology and translational research.
  • Analyzing the utility of current animal models for glaucoma research.
  • Identifying gaps in preclinical research tools, particularly for normal-tension glaucoma.
  • Outlining discoveries from cell-based, animal, and translational studies.

Main Results:

  • The development of integrated research maps and consensus statements is essential for accelerating glaucoma therapy.
  • Existing animal models have limitations, and there is a specific need for models of normal-tension glaucoma.
  • Progress has been made in mapping glaucoma from cell biology to disease pathology, but further community input is required.

Conclusions:

  • Establishing comprehensive research maps and consensus is critical for advancing glaucoma treatment.
  • Collaborative efforts within the global glaucoma research community are necessary to complete these maps.
  • Accelerated basic science research, guided by these efforts, will lead to significant clinical advancements for patients.