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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Updated: Feb 25, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

CNT-decellularized cartilage hybrids for tissue engineering applications.

Toktam Ghassemi¹, Nasser Saghatolslami, Maryam M Matin

¹Department of Chemical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.

Biomedical Materials (Bristol, England)

|August 5, 2017

Summary

This summary is machine-generated.

Incorporating carbon nanotubes (CNTs) into decellularized articular cartilage (AC) significantly enhances its mechanical strength and biocompatibility. This CNT-reinforced AC shows promise as an advanced scaffold for cartilage tissue engineering and repair applications.

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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

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Published on: January 7, 2019

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3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Articular cartilage (AC) repair requires scaffolds with adaptable architectural and biochemical properties.
Decellularized extracellular matrix (ECM)-derived scaffolds offer a promising avenue for AC repair.
Enhancing the mechanical properties of decellularized AC scaffolds is crucial for effective regeneration.

Purpose of the Study:

To evaluate reinforced decellularized bovine AC as a potential scaffold for cartilage repair.
To investigate the impact of incorporating single-wall carbon nanotubes (CNTs) on scaffold properties.
To assess the mechanical, thermodynamic, and biocompatibility characteristics of CNT-incorporated AC scaffolds.

Main Methods:

Chemically decellularized bovine AC samples were prepared.
Individually dispersed single-wall carbon nanotubes (CNTs) were incorporated into the AC scaffolds.
Mechanical (compressive test, Young's modulus), thermodynamic (FTIR, TGA, DSC), and biocompatibility (resazurin test, SEM with hADSCs) analyses were performed.

Main Results:

CNT-incorporated AC scaffolds exhibited a significantly higher Young's modulus (0.67 ± 0.09 MPa) compared to decellularized AC (0.43 ± 0.06 MPa).
Enhanced cell proliferation of human-adipose-derived stem cells (hADSCs) was observed on CNT-incorporated scaffolds after 7 days.
FTIR, TGA, and DSC confirmed improved stability of decellularized AC upon CNT incorporation.

Conclusions:

Incorporation of CNTs substantially enhances the mechanical properties of decellularized AC.
CNT-reinforced decellularized AC scaffolds maintain excellent biocompatibility.
These findings suggest CNT-incorporated decellularized AC as a promising scaffold for cartilage tissue engineering.