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Updated: Feb 25, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
Published on: May 9, 2017
An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences
Su Datt Lam1, Sayoni Das1, Ian Sillitoe1
1Institute of Structural and Molecular Biology, UCL, Darwin Building, Gower Street, London WC1E 6BT, England.
Abstract:
Computational modelling of proteins has been a major catalyst in structural biology. Bioinformatics groups have exploited the repositories of known structures to predict high-quality structural models with high efficiency at low cost. This article provides an overview of comparative modelling, reviews recent developments and describes resources dedicated to large-scale comparative modelling of genome sequences. The value of subclustering protein domain superfamilies to guide the template-selection process is investigated. Some recent cases in which structural modelling has aided experimental work to determine very large macromolecular complexes are also cited.
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