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Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.
Rine Nakanishi1, Wendy S Post2,3, Kazuhiro Osawa1
1Department of Cardiology, Los Angeles Biomedical Research Institute.
Coronary Artery Disease
|August 5, 2017
Summary
This study quantifies coronary atherosclerosis progression in men with HIV using serial coronary CT angiography. Findings will improve understanding of cardiovascular disease in HIV-infected individuals.
Area of Science:
- Cardiovascular disease research
- HIV/AIDS research
- Medical imaging analysis
Background:
- Established association between HIV and coronary atherosclerosis.
- Limited knowledge on the longitudinal progression of coronary atherosclerosis in HIV-infected individuals.
- Need for quantitative assessment of plaque changes over time.
Purpose of the Study:
- To quantify the progression of coronary atherosclerosis in HIV-infected and uninfected men.
- To analyze changes in coronary plaque volume and characteristics over time.
- To investigate vulnerable plaque development in the context of HIV infection.
Main Methods:
- Prospective, multicenter study design (Multicenter AIDS Cohort Study Cardiovascular Substudy).
- Serial contrast coronary computed tomography angiography (CTA) performed 3-6 years after baseline.
- Semiautomated software used to measure coronary plaque volume, characteristics (calcified, noncalcified, low attenuation), and vulnerable plaque.
Main Results:
- The study successfully enrolled HIV-infected and uninfected men for serial CTA.
- Quantitative measurements of coronary plaque progression were obtained.
- Detailed analysis of plaque characteristics and vulnerable plaque incidence was performed.
Conclusions:
- This study presents a novel, large-scale prospective investigation into coronary atherosclerosis progression.
- Quantitative assessment using serial coronary CTAs provides detailed insights into plaque changes.
- Findings will elucidate the impact of HIV on the longitudinal development of coronary atherosclerosis.
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