Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insomnia01:27

Insomnia

515
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
515
Management of Insomnia01:19

Management of Insomnia

732
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
732
Narcolepsy01:07

Narcolepsy

622
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
622
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.1K
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

1.5K
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
1.5K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

978
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
978

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep Disturbances Among Yazidi Survivors of the ISIS Genocide: Epidemiology, Neuropsychology, and Culturally Sensitive Interventions.

Brain and behavior·2026
Same author

The Prodromal Synucleinopathy Rating Scale: An Assessment in Patients With REM Sleep Behavior Disorder.

Neurology·2026
Same author

Sleep health and mental health: A position statement from the National Sleep Foundation.

Sleep health·2026
Same author

The North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder.

Sleep advances : a journal of the Sleep Research Society·2026
Same author

Real-world data on the abuse potential of medications for the treatment of insomnia: a disproportionality analysis of the FAERS database.

Frontiers in pharmacology·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same journal

Neurology's Action Potential: Delivering on the Promise of Brain Health.

Continuum (Minneapolis, Minn.)·2026
Same journal

Erratum.

Continuum (Minneapolis, Minn.)·2026
Same journal

Management of Large Artery Atherosclerosis.

Continuum (Minneapolis, Minn.)·2026
Same journal

Thrombolysis, Thrombectomy, and Antithrombotic Therapy for Acute Ischemic Stroke.

Continuum (Minneapolis, Minn.)·2026
Same journal

Stroke in Children and Younger Adults.

Continuum (Minneapolis, Minn.)·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.6K

Chronic Insomnia Disorder.

Alon Y Avidan, David N Neubauer

    Continuum (Minneapolis, Minn.)
    |August 5, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Insomnia significantly impacts neurological conditions, often linked to comorbidities. A multidisciplinary approach combining cognitive-behavioral therapy and FDA-approved medications is essential for effective insomnia treatment in neurology patients.

    More Related Videos

    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
    04:53

    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

    Published on: October 18, 2024

    1.5K
    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
    06:23

    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

    Published on: September 22, 2020

    6.1K

    Related Experiment Videos

    Last Updated: Feb 25, 2026

    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
    05:34

    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

    Published on: August 18, 2023

    3.6K
    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
    04:53

    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

    Published on: October 18, 2024

    1.5K
    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
    06:23

    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

    Published on: September 22, 2020

    6.1K

    Area of Science:

    • Neurology
    • Sleep Medicine
    • Pharmacology

    Background:

    • Insomnia is a common sleep disturbance frequently encountered by healthcare providers, impacting neurological conditions bidirectionally.
    • Patients often underreport insomnia, frequently associating it with other medical issues rather than as an independent condition.
    • Factors such as pain, movement disorders, sleep apnea, and central nervous system medications contribute to insomnia in neurological practice.

    Purpose of the Study:

    • To provide an evidence-based, multidisciplinary approach to insomnia treatment in neurology.
    • To highlight the importance of assessing comorbidities impacting insomnia.
    • To discuss the utility of cognitive-behavioral therapy and pharmacologic interventions.

    Main Methods:

    • Review of current literature on insomnia in neurological patients.
    • Analysis of FDA-approved pharmacologic treatments targeting specific receptor systems.
    • Emphasis on a comprehensive, multidisciplinary assessment strategy.

    Main Results:

    • Several FDA-approved medications exist for insomnia, including GABA-modulating benzodiazepine receptor agonists, melatonin receptor agonists, histamine receptor antagonists, and hypocretin (orexin) receptor antagonists.
    • Cognitive-behavioral therapy (CBT) and pharmacologic interventions are key components of effective insomnia treatment.
    • Neurologists must proactively assess comorbidities like depression, circadian rhythm disorders, and nocturia.

    Conclusions:

    • An all-inclusive approach is necessary for evaluating sleep problems in patients with insomnia.
    • Tailored therapeutic strategies incorporating CBT and targeted pharmacotherapy are crucial.
    • Addressing underlying neurological and psychiatric conditions is vital for managing insomnia effectively.