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Updated: Feb 25, 2026

Transthoracic Echocardiography in Mice
Published on: May 28, 2010
An Interposed Pad in Open-Chest Echocardiographic Porcine Scans for Mimicking Ultrasound Signal Attenuation in a
Randall R Kinnick1, Minako Katayama2, Marek Belohlavek2
1Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Abstract:
Opening a chest in an experimental echocardiographic animal study eliminates ultrasound signal attenuation by the chest wall. We developed a scanning technique that involves the use of an attenuative pad created from a mixture of urethane and titanium dioxide. The pad was interposed within transmission gel between the transducer face and cardiac surface in open-chest scans in a porcine model. Comparative measurements of left ventricular echogenicity without and with the pad demonstrate that the pad reproducibly causes ultrasound signal attenuation that closely mimics chest attenuation in clinical transthoracic echocardiographic studies.
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