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Updated: Feb 25, 2026

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Structural Alterations in Chronic Capsular versus Pontine Stroke.

Lin Jiang1, Jingchun Liu1, Caihong Wang1

  • 1From the Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China (L.J., J.L., C.Y.); School of Medical Imaging, Tianjin Medical University, Tianjin, China (L.J.); Department of MR imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (C.W., J.C., P.M.); and Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China (J.G., T.H., C.C.).

Radiology
|August 5, 2017
PubMed
Summary

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Capsular and pontine strokes cause distinct brain structural changes. These differences in gray matter volume in areas like the insula, motor cortex, and cerebellum highlight unique damage patterns for targeted stroke rehabilitation.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Stroke is a leading cause of long-term disability.
  • Understanding structural brain changes after stroke is crucial for rehabilitation.

Purpose of the Study:

  • To compare structural brain damage and reorganization in capsular stroke (CS) versus pontine stroke (PS) involving motor pathways.

Main Methods:

  • Prospective acquisition of structural MRI data from 115 CS patients, 47 PS patients, and 116 controls.
  • Voxel-wise comparison of gray matter volume (GMV) across groups, controlling for age, sex, and imager.
  • Statistical correction using false discovery rate and Bonferroni methods.

Main Results:

  • Both CS and PS groups showed reduced GMV in the ipsilesional anterior insular cortex and increased GMV in the supplementary motor area compared to controls.

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  • CS patients exhibited GMV reduction in the ipsilesional sensorimotor cortex.
  • PS patients showed GMV reduction in the cerebellum and specific increases in the precuneus (left lesions) or middle frontal gyrus (right lesions).

    • Conclusions:

    • Distinct patterns of structural damage and reorganization exist between capsular stroke and pontine stroke.
    • These findings can inform the development of individualized rehabilitation strategies for stroke patients.