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Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Systematic review and Knowledge Translation: A framework for synthesizing heterogeneous research evidence
Robert Gould1, Sarah Parker Harris1, Glenn Fujiura1
1Department of Disability and Human Development, University of Illinois-Chicago, Chicago, IL, USA.
Background:
Participatory methodologies in disability and rehabilitation research are used to capture the perspectives of people with disabilities and to recognize the agency of stakeholder groups. Existing resources for conducting systematic reviews seldom provide details about how to integrate stakeholder input into the methodological process.
Objectives:
This article considers how knowledge translation strategies can support and advance systematic reviews that include diverse types of research.
Methods:
Lessons learned from conducting a systematic review of Americans with Disabilities Act (ADA) employment research are explained and contextualized within research on barriers and facilitators to successful knowledge translation.
Results:
Steps from the research protocol are described to provide a procedural framework for integrating stakeholder feedback into the review process. Descriptive mapping, an analytical technique most commonly used in scoping reviews, was deemed necessary to provide a clearer understanding and overview of the diverse body of research evidence.
Conclusions:
Stakeholder feedback can address barriers to knowledge translation by engaging end-users of research products throughout the review process. Given the growing scholarly recognition of qualitative and mixed-methods techniques as suitable approaches for systematic review, there is further need for consideration on how these approaches can benefit from more participatory research processes.
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