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[Association of endotheline receptor gene rs1878406 polymorphism with severe multi-vessel coronary disease]

Liyun Zhang1, Juan Chen, Qin He

  • 1Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei 430015, China. grasscloudy1979@163.com.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|August 5, 2017
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in the endotheline receptor gene were studied for association with coronary heart disease (CHD) severity. The rs1878406 polymorphism may indicate severe multi-vessel disease in Han Chinese patients.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Pharmacogenomics

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Genetic factors play a crucial role in CHD susceptibility and severity.
  • Endotheline receptor gene polymorphisms are investigated for their potential role in cardiovascular disease.

Purpose of the Study:

  • To investigate the association between specific single nucleotide polymorphisms (SNPs) in the endotheline receptor gene and the severity of coronary heart disease (CHD).
  • To identify potential genetic markers for predicting severe multi-vessel disease in CHD patients.

Main Methods:

  • A case-control study involving 553 CHD patients and 553 controls.
  • Genotyping of four endotheline receptor gene SNPs (rs501120, rs899997, rs1878406, rs7173743) using TaqMan-MGB probes.
  • Logistic regression analysis adjusted for conventional risk factors.

Main Results:

  • The A allele of rs501120 and T allele of rs1878406 were more frequent in the CHD group.
  • The rs1878406 TT+TC genotype was significantly associated with severe multi-vessel disease (OR=1.43, P=0.033) after adjustment.
  • No significant differences were found for rs7173743 and rs899997.

Conclusions:

  • The rs1878406 polymorphism in the endotheline receptor gene may serve as a genetic marker for severe multi-vessel coronary heart disease.
  • This finding is specific to the ethnic Han Chinese population studied.
  • Further research is warranted to validate these genetic associations in diverse populations.
Abstract

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