Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CRISPR01:59

CRISPR

58.2K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
58.2K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

2.1K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
2.1K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.6K
Overview
80.6K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

17.1K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
17.1K
Homologous Recombination02:31

Homologous Recombination

64.2K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
64.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rare disease genomics and justice: overview of a workshop at the Fondation Brocher, 22-24 January 2025.

Journal of community genetics·2026
Same author

Views of the Swiss public towards gene editing.

PloS one·2026
Same author

Newborn Sequencing: The Promise and Perils.

Annual review of genomics and human genetics·2026
Same author

Safety and pharmacokinetics of sulfasalazine and its metabolite sulfapyridine for treatment of preterm preeclampsia in Australia (SIP): an early phase, unblinded, single-arm, proof of concept clinical trial.

EClinicalMedicine·2026
Same author

Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.

Annals of the rheumatic diseases·2026
Same author

The impacts of pricing and reimbursement policies on access to cell and gene therapies across Europe.

Journal of community genetics·2026
Same journal

Bi-allelic missense variants in human GPN2 result in Perrault syndrome.

American journal of human genetics·2026
Same journal

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics·2026
Same journal

A transparent and generalizable deep-learning framework for genomic ancestry prediction.

American journal of human genetics·2026
Same journal

Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome.

American journal of human genetics·2026
Same journal

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

American journal of human genetics·2026
Same journal

Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

American journal of human genetics·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

13.6K

Human Germline Genome Editing.

Kelly E Ormond1, Douglas P Mortlock2, Derek T Scholes3

  • 1Department of Genetics and Stanford Center for Biomedical Ethics, School of Medicine, Stanford University, Stanford, CA 94305, USA.

American Journal of Human Genetics
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Germline gene editing for human pregnancy is currently inappropriate due to unresolved scientific and ethical questions. Research on human embryos and gametes is permissible with oversight, but future clinical applications require compelling justification and public input.

Keywords:
CRISPRethicseugenicsgene editinggene therapygenetics policygenome editinggermlinehuman genomesociety

More Related Videos

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

8.9K
CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
08:22

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy

Published on: March 12, 2018

15.7K

Related Experiment Videos

Last Updated: Feb 25, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

13.6K
Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

8.9K
CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
08:22

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy

Published on: March 12, 2018

15.7K

Area of Science:

  • Genetics
  • Bioethics
  • Reproductive Medicine

Background:

  • Genome-editing technologies like CRISPR/Cas9 are advancing rapidly, making somatic and germline editing feasible.
  • An American Society of Human Genetics (ASHG) workgroup convened to address the implications of these technologies.

Purpose of the Study:

  • To establish a position statement on the ethical and scientific considerations of human germline genome editing.
  • To guide future research and clinical applications of gene editing technologies.

Main Methods:

  • Development of a position statement by a multidisciplinary workgroup.
  • Endorsement of the statement by numerous international genetic and reproductive medicine societies.

Main Results:

  • It is currently inappropriate to perform germline gene editing resulting in human pregnancy due to unanswered questions.
  • In vitro germline genome editing on embryos and gametes for research is permissible with oversight and consent.
  • Public funding for such research should not be prohibited.

Conclusions:

  • Future clinical use of human germline gene editing requires a compelling medical rationale, robust evidence, ethical justification, and public input.
  • A transparent public process is essential for incorporating stakeholder perspectives.
  • The statement outlines conditions for the responsible advancement of germline gene editing.