Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

319
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
319
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

278
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
278
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

298
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
298
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

761
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
761
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

267
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
267
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obstructive sleep apnea in those with idiopathic intracranial hypertension undergoing diagnostic in-laboratory polysomnography.

Sleep medicine·2024
Same author

Obstructive Sleep Apnea in Men With Idiopathic Intracranial Hypertension: A Prospective Case-Control Study.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2022
Same author

Reversible neurological and brain MRI changes following COVID-19 vaccination: A case report.

Journal of neuroradiology = Journal de neuroradiologie·2022
Same author

A Transdiagnostic Self-management Web-Based App for Sleep Disturbance in Adolescents and Young Adults: Feasibility and Acceptability Study.

JMIR formative research·2021
Same author

Long-term effects of solriamfetol on quality of life and work productivity in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2021
Same author

Does sodium oxybate inhibit brain dopamine release in humans? An exploratory neuroimaging study.

Human psychopharmacology·2021

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

3.2K

Sleepiness in the Elderly.

Dora Zalai1, Arina Bingeliene2, Colin Shapiro2

  • 1Department of Psychology, Ryerson University, 790 Bay Street, Toronto, Ontario M5B 2K8, Canada.

Sleep Medicine Clinics
|August 6, 2017
PubMed
Summary
This summary is machine-generated.

Excessive daytime sleepiness in older adults requires medical attention due to potential underlying causes and adverse outcomes like cognitive decline. A systematic approach to diagnosis and treatment is essential for preventing negative health consequences.

Keywords:
ElderlyExcessive daytime sleepinessOlder adults

More Related Videos

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.3K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.2K

Related Experiment Videos

Last Updated: Feb 25, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

3.2K
Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.3K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.2K

Area of Science:

  • Gerontology
  • Sleep Medicine
  • Neurology

Background:

  • Excessive daytime sleepiness (EDS) is a common and serious issue in older adults.
  • EDS can stem from multifactorial causes including sleep disorders, medical conditions, mood disorders, and medication side effects.
  • Sleepiness in the elderly is linked to a higher risk of cognitive decline and dementia.

Purpose of the Study:

  • To highlight the importance of medical attention for EDS in older adults.
  • To emphasize the multifactorial nature of EDS in this population.
  • To underscore the association between EDS and cognitive decline.

Main Methods:

  • Multi-method assessment is often necessary for diagnosing EDS in older adults.
  • A systematic, step-by-step treatment approach is recommended.
  • Treatment should target the underlying cause of sleepiness.

Main Results:

  • EDS in older adults is frequently multifactorial.
  • EDS is a significant risk factor for cognitive impairment and dementia.
  • Prompt medical attention and targeted treatment are crucial.

Conclusions:

  • Addressing EDS in older adults is critical for preventing adverse health outcomes.
  • A comprehensive diagnostic and therapeutic strategy is essential.
  • Early intervention can mitigate risks associated with excessive sleepiness.