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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
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Melt-Cast Noninvasive Ocular Inserts for Posterior Segment Drug Delivery
Sai Prachetan Balguri1, Goutham R Adelli1, Akshaya Tatke1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi 38677.
Journal of Pharmaceutical Sciences
|August 6, 2017
Summary
Melt-cast ocular inserts effectively delivered drugs with varying properties. These novel inserts significantly enhanced drug permeation and ocular tissue distribution compared to traditional solutions.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Materials Science
Background:
- Ocular drug delivery faces challenges due to the eye's biological barriers.
- Developing effective topical ocular drug delivery systems is crucial for treating eye diseases.
Purpose of the Study:
- To evaluate melt-cast ocular inserts for delivering drugs with diverse physicochemical properties.
- To assess the utility of polyethylene oxide N10 as a matrix for ophthalmic inserts.
Main Methods:
- Fabrication of melt-cast ophthalmic inserts using polyethylene oxide N10.
- Testing of inserts with indomethacin, ciprofloxacin hydrochloride, and prednisolone sodium phosphate.
- In vitro release, transmembrane permeability, and in vivo ocular tissue distribution studies were performed.
Main Results:
- Drug content in inserts ranged from 93% to 102%.
- Polymeric inserts enhanced transmembrane flux by 2.9- to 3.6-folds compared to controls.
- Significantly higher drug levels were observed in ocular tissues, including retina-choroid.
Conclusions:
- Melt-cast ophthalmic inserts demonstrate potential as an effective noninvasive ocular drug delivery platform.
- This technology offers benefits for treating various ocular complications.
Keywords:
anti-inflammatory drugsocular bioavailabilityocular deliveryocular insertsocular penetrationtopical polymeric insertsMore Related Videos
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