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Review of various molecular targets on mast cells and its relation to obesity: A future perspective

Souravh Bais1, Reena Kumari1, Yash Prashar1

  • 1Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra, SBS Nagar District, Punjab 144506, India.

Diabetes & Metabolic Syndrome
|August 6, 2017
PubMed

Insights

This review explores molecular targets to suppress mast cell overexpression in obesity. Understanding mast cell roles in metabolic diseases offers new therapeutic avenues.

Area of Science:

  • Immunology
  • Metabolic Diseases
  • Cell Biology

Background:

  • Mast cells are key players in allergic and immunological diseases.
  • Their role in metabolic diseases, including obesity, is increasingly recognized.
  • Overexpression of mast cells contributes to disease pathology.

Purpose of the Study:

  • To review the literature on mast cells and obesity.
  • To identify molecular targets for suppressing mast cell activity in obesity.
  • To explore the connection between mast cells and metabolic diseases.

Main Methods:

  • Comprehensive literature search of databases (PubMed, Scopus, Web of Science, Google Scholar) over the last 20 years.
  • Keywords used: "Mast Cell", "obesity", "role of mast cell or role in obesity".
  • Review and selection of 87 relevant publications from 827 initial articles.

Main Results:

  • Mast cells exhibit diverse characteristics relevant to obesity.
  • Several molecular targets have been identified for mast cell suppression.
  • Evidence links mast cell activity to various metabolic dysfunctions in obesity.

Conclusions:

  • Mast cells are significant contributors to obesity and related metabolic disorders.
  • Targeting mast cells presents a potential therapeutic strategy for obesity.
  • Further research is warranted to elucidate specific molecular pathways and therapeutic interventions.
Keywords:
Adipose tissueMast cellsMolecular targetsObesity

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