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The impact of continuous renal replacement therapy for metabolic disorders in infants

Fatih Aygun1, Deniz Aygun2, Firuze Erbek Alp3

  • 1Istanbul University, Cerrahpasa Medical Faculty, Department of Pediatric Intensive Care Unit, Istanbul, Turkey.

Pediatrics and Neonatology
|August 6, 2017
PubMed

Insights

Continuous Renal Replacement Therapy (CRRT) effectively manages metabolic emergencies like hyperammonemia and high leucine levels in pediatric patients. This study highlights CRRT

Area of Science:

  • Pediatric Critical Care Medicine
  • Nephrology
  • Metabolic Disorders

Background:

  • Continuous Renal Replacement Therapy (CRRT) is established for acute kidney insufficiency (AKI).
  • Emerging use of CRRT in managing acute metabolic disorders, including hyperammonemia and elevated leucine levels.
  • Study focuses on CRRT application in a pediatric intensive care unit (PICU) setting.

Purpose of the Study:

  • To describe the experience with CRRT in treating acute decompensation of pediatric patients with metabolic disorders.
  • To evaluate the efficacy of CRRT in managing hyperammonemia and elevated leucine levels.
  • To report on the application of CRRT in a PICU over a one-year period.

Main Methods:

  • Retrospective evaluation of pediatric patients treated with CRRT for acute metabolic crisis.
  • Analysis of 14 patients admitted to the PICU between November 2014 and December 2015.
  • Inclusion of patients with hyperammonemia and elevated leucine levels due to various metabolic disorders.

Main Results:

  • 14 pediatric patients received CRRT for metabolic disorders.
  • 10 patients had hyperammonemia, and 4 had elevated leucine levels.
  • CRRT modalities included continuous veno-venous hemodiafiltration (CVVHDF) and continuous veno-venous hemodialysis (CVVHD) with high throughput settings.

Conclusions:

  • CRRT is an efficient treatment for metabolic emergencies such as hyperammonemia and elevated leucine levels.
  • The study supports the use of CRRT in managing severe metabolic decompensation in pediatric patients.
  • CRRT demonstrates effectiveness in addressing life-threatening metabolic crises.
Abstract

Keywords:
childhyperammonemialeucinemetabolic emergencyrenal replacement therapy

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