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Generation of Organoids from Mouse Extrahepatic Bile Ducts

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Published on: April 23, 2019

Repopulating the biliary tree from the peribiliary glands.

Iris E M de Jong¹, Otto B van Leeuwen¹, Ton Lisman²

¹Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, The Netherlands; Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.

Biochimica Et Biophysica Acta. Molecular Basis of Disease

|August 6, 2017

Summary

Peribiliary glands (PBG) are crucial for biliary epithelial cell renewal and regeneration. Understanding PBG function offers potential for new therapies in liver and bile duct diseases.

Keywords:

Bile duct Biliary epithelium Cholangiopathies Liver Peribiliary glands Regeneration

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Area of Science:

Hepatology
Gastroenterology
Cell Biology

Background:

Peribiliary glands (PBG) are tubulo-alveolar glands in larger biliary ducts, historically noted but recently understood.
Their role in bile secretion is now secondary to their function in biliary epithelial cell proliferation and renewal.

Purpose of the Study:

To elucidate the function of PBG in biliary epithelial cell biology.
To explore the role of PBG in cholangiopathies and bile duct malignancies.
To investigate the potential of PBG as stem/progenitor cell niches for regenerative medicine.

Main Methods:

Review of recent scientific literature on PBG.
Analysis of studies linking PBG characteristics to cholangiopathies.
Investigation of PBG as stem cell niches.

Main Results:

PBG are identified as key sources for biliary epithelial cell proliferation and renewal.
PBG activation, dilatation, or lack thereof correlates with various cholangiopathies.
PBG serve as niches for multipotent stem/progenitor cells with endodermal traits.

Conclusions:

PBG play a significant role in biliary homeostasis and regeneration.
Dysregulation of PBG is implicated in cholangiopathies and bile duct cancers.
Harnessing PBG's regenerative capacity may lead to novel therapeutic strategies for hepatobiliary diseases.