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Acute changes in renal function induced by bisoprolol, a new cardioselective beta-blocking agent
European Journal of Clinical Pharmacology
|January 1, 1986
Summary
Bisoprolol, a beta1-selective adrenoceptor antagonist, significantly reduced heart rate and depressed plasma renin activity in hypertensive patients. Acute kidney function changes were observed, potentially linked to reduced cardiac output.
Area of Science:
- Pharmacology
- Nephrology
- Cardiology
Background:
- Essential hypertension poses significant cardiovascular and renal risks.
- Beta-blockers are commonly used in hypertension management.
- Bisoprolol is a selective beta1-adrenoceptor antagonist with potential renal effects.
Purpose of the Study:
- To investigate the acute effects of intravenous bisoprolol on cardiovascular and renal function in patients with essential hypertension.
- To assess the impact of bisoprolol on glomerular filtration rate (GFR) and para-aminohippuric acid clearance (CPAH).
Main Methods:
- A study involving 6 patients with essential hypertension.
- Administration of bisoprolol 10 mg intravenously.
- Monitoring of heart rate, mean blood pressure (mBP), GFR, CPAH, sodium clearance, urine volume, and plasma renin activity (PRA).
Main Results:
- Heart rate decreased by 23% and PRA by 25%.
- GFR and CPAH decreased by 14% and 23%, respectively.
- No significant changes in mBP, urine volume, or sodium clearance were observed.
Conclusions:
- Bisoprolol acutely reduces heart rate and depresses PRA in hypertensive patients.
- Acute renal function changes, including decreased GFR and CPAH, are associated with bisoprolol administration.
- These renal effects may be attributed to reduced cardiac output and increased systemic vascular resistance.