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Updated: Feb 25, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia
Henrik Lilljebjörn1, Thoas Fioretos1,2
1Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden, and.
Abstract:
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1-like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.
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