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Altered brain network measures in patients with primary writing tremor
Abhishek Lenka1,2, Ketan Ramakant Jhunjhunwala1,2, Rajanikant Panda3
1Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India.
Neuroradiology
|August 6, 2017
Summary
Primary writing tremor (PWT) patients exhibit altered brain connectivity. Graph theory analysis revealed reduced small-world network efficiency in the cerebellum and prefrontal cortex of individuals with PWT.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Primary writing tremor (PWT) is a rare, task-specific tremor.
- The underlying pathophysiology of PWT remains poorly understood.
- Understanding brain connectivity alterations is crucial for PWT research.
Purpose of the Study:
- To investigate resting-state functional brain connectivity in PWT patients.
- To utilize graph theory-based analysis to identify network alterations.
- To compare brain connectivity between PWT patients and healthy controls.
Main Methods:
- A prospective case-control study involving 10 PWT patients and 10 healthy controls.
- Magnetic Resonance Imaging (MRI) was conducted using a 3-Tesla scanner.
- Graph theory analysis was applied to compare small-world functional connectivity parameters.
Main Results:
- No significant demographic differences were observed between PWT patients and controls.
- PWT patients demonstrated a significantly lower clustering coefficient and higher path length.
- Altered connectivity was noted in the bilateral medial cerebellum, right dorsolateral prefrontal cortex (DLPFC), and left posterior parietal cortex (PPC).
Conclusions:
- PWT is associated with significant alterations in small-world brain connectivity.
- Specific regions like the cerebellum, DLPFC, and PPC show altered connectivity in PWT.
- Larger sample studies are needed to validate these findings.
