Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation of non-specific bronchial reactivity.

A Mistretta, N Crimi, F Palermo

    International Journal of Tissue Reactions
    |January 1, 1986
    PubMed
    Summary

    Several drugs can temporarily reduce bronchial hyperreactivity, but no specific medications directly target and permanently modify this condition. Current treatments focus on reducing inflammatory mediators and inhibiting reflex bronchoconstriction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Barriers to accessing healthcare for people with disabilities:a systematic review.

    Frontiers in public health·2026
    Same author

    Innovative socio-sanitary rehabilitation models in central nervous system disorders: a systematic review.

    Frontiers in public health·2026
    Same author

    Re-treatment with panitumumab followed by regorafenib versus the reverse sequence in chemorefractory metastatic colorectal cancer patients with RAS and BRAF wild-type circulating tumor DNA: the PARERE study by GONO.

    Annals of oncology : official journal of the European Society for Medical Oncology·2025
    Same author

    Impact of age and sex on the efficacy and safety of ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line oxaliplatin-based chemotherapy: a subgroup analysis of the ARMANI phase III trial.

    ESMO open·2025
    Same author

    Tremelimumab and durvalumab as neoadjuvant or non-operative management strategy of patients with microsatellite instability-high resectable gastric or gastroesophageal junction adenocarcinoma: the INFINITY study by GONO.

    Annals of oncology : official journal of the European Society for Medical Oncology·2024
    Same author

    Are we overlooking the lung function in the definition of severe asthma remission?

    Pulmonology·2023

    Area of Science:

    • Pharmacology
    • Respiratory Medicine
    • Immunology

    Background:

    • Bronchial hyperreactivity is a key feature of asthma, increasing airway sensitivity to various stimuli.
    • Current understanding of drugs modifying bronchial hyperreactivity is limited, particularly regarding their mechanisms of action.

    Purpose of the Study:

    • To review existing pharmacological approaches to managing bronchial hyperreactivity.
    • To explore potential mechanisms of action for drugs affecting non-specific airway reactivity.

    Main Methods:

    • Literature review of studies on drugs influencing bronchial hyperreactivity.
    • Analysis of proposed mechanisms, including mast cell stabilization, calcium channel blockade, and beta-2 adrenergic activity.

    Main Results:

    • Disodium cromoglycate (DSCG) reduces bronchial hyperreactivity, possibly via mast cell stabilization or calcium channel blockade.
    • Beta-2 adrenergic drugs are effective in exercise-induced bronchospasm, though the exact mechanism remains unclear.
    • Theophylline shows protective effects against histamine-induced bronchospasm, dependent on blood levels.
    • Anticholinergic drugs offer limited protection against various stimuli.

    Conclusions:

    • Many available drugs offer transient modification of bronchial hyperreactivity.
    • Existing anti-asthmatic drugs decrease hyperreactivity by reducing inflammatory mediators and inhibiting reflex bronchoconstriction.
    • Currently, no specific drugs directly target and permanently modify bronchial hyperreactivity.

    Related Experiment Videos