Cupping regulates local immunomodulation to activate neural-endocrine-immune worknet
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Updated: Feb 25, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
Published on: June 13, 2011
Yang Guo1, Bo Chen2, Dong-Qiang Wang3
1Graduate Institution, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Abstract:
Research on cupping therapy is lacking at home and abroad. However, cupping and acupuncture therapy are both surface stimulation therapies. This paper suggests the mechanism of cupping therapy and proposes that the same mechanism underlies both cupping and acupuncture therapy. The microenvironment is changed when stimulating the surface of the skin, and physical signals transform into biological signals, which also interact with each other in the body. These signalling cascades activate the neuroendocrine-immune system, which produces the therapeutic effect.
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