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Updated: Feb 25, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation
Amir Tajbakhsh1, Mehdi Rezaee2, Mahdi Rivandi1
1Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran.
Abstract:
Ischaemic stroke, which is mostly caused by atherosclerosis, is one of the most widely causes of mortality and morbidity. One of the most important enzymatic activities of paraoxonase-1 (PON1) in association with high-density lipoprotein (HDL) is the prevention of low-density lipoprotein (LDL) oxidation, which gives it an anti-atherogenic activity. PON1 expression and activity is influenced by various factors; the most important of which is genetic polymorphism, mainly single nucleotide polymorphisms (SNPs). The results of various studies in different populations indicate that some SNPs of the PON1 gene are associated with stroke. Therefore, in this review we studied various researches, in which the association of PON1 SNPs with stroke had been investigated in different populations.
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