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Related Experiment Video

Updated: Feb 25, 2026

Ultrasound Tissue Characterization of Human Achilles Tendon by Stability Quantification of Echo Patterns

Ultrasound Tissue Characterization of Human Achilles Tendon by Stability Quantification of Echo Patterns

Published on: September 5, 2025

Ultrashort echo time T2^∗ values decrease in tendons with application of static tensile loads.

Saeed Jerban¹, Amin Nazaran¹, Xin Cheng²

¹Department of Radiology, University of California, San Diego, CA, USA.

Journal of Biomechanics

|August 7, 2017

Summary

This summary is machine-generated.

Ultrashort echo time MRI detected significant changes in tendon T2* values under static load, indicating altered biomechanics before anatomical changes occur. This suggests T2* monitoring can quantitatively assess tendon health.

Keywords:

MRI T2(∗)Tendon Tensile loading Ultrashort TE

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Area of Science:

Biomedical Engineering
Radiology
Orthopedics

Background:

Tendon disease can alter mechanical properties before visible anatomical changes.
Ultrashort echo time (UTE) magnetic resonance imaging (MRI) detects signals from tissues with very short T2 values, like tendons.
UTE MRI offers a potential method to assess tendon viscoelasticity.

Purpose of the Study:

To investigate variations in T2*, T1, and magnetization transfer ratio (MTR) of human peroneal tendons under static tensile loads using UTE MRI.
To determine if UTE MRI parameters can detect early mechanical changes in tendons.

Main Methods:

Six human peroneal tendons were imaged using UTE sequences on a 3T MRI scanner.
Tendons were subjected to one-step (15N) or two-step (15N and 30N) static tensile loading.
T2*, T1, and MTR variations were analyzed in whole and core tendon regions of interest (ROIs).

Main Results:

Mean T2* values significantly decreased with the first loading step (15N) by 13% in whole sections and 16% in core sections (P<0.05).
A further, non-significant decrease in T2* was observed with the second loading step (30N).
No consistent significant changes were found for T1 or MTR values under loading (P>0.05).

Conclusions:

Significant changes in tendon T2* values were observed under static tensile load.
T2* monitoring during loading shows promise for quantitative assessment of tendon biomechanics.
UTE MRI can detect early mechanical alterations in tendons, potentially aiding in early disease detection.