Arginine-leucine based poly (ester urea urethane) coating for Mg-Zn-Y-Nd alloy in cardiovascular stent applications

Selected from the family of self-designed biodegradable amino acid-based poly (ester urea urethane) (AA-PEUU) pseudo-protein biomaterials, arginine-leucine based poly (ester urea urethane)s (Arg-Leu-PEUUs) were used as protective and bio-functional coatings for bio-absorbable magnesium alloy MgZnYNd in cardiovascular stent applications. Comparing with poly (glycolide-co-lactide) (PLGA) coating, the Arg-Leu-PEUU coating had stronger bonding strength with the substrate; in vitro electrochemical and long-term immersion results verified a significantly better corrosion resistance. Acute blood contact tests proved a better hemocompatibility of Arg-Leu-PEUU coating. The immunofluorescent staining and cell proliferation test indicated that Arg-Leu-PEUU coating had a far better cytocompatibility. The Arg-Leu-PEUU coating stimulated human umbilical vein endothelial cells (HUVEC) to release reasonably increased amount of nitric oxide (NO), suggesting its potential in retarding thrombosis and restenosis. The superior corrosion resistance and biocompatibility as well as the indigenous NO production bio-functionality of the Arg-Leu-PEUU copolymer family indicate their capability to offer a far better protection of the magnesium-based implantable cardiovascular stent and bring their application closer to clinical reality.