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Updated: Feb 25, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Known unknowns: how might the persistent herpesvirome shape immunity and aging?

Janko Nikolich-Zugich1, Felicia Goodrum1, Kenneth Knox2

  • 1Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States.

Current Opinion in Immunology
|August 7, 2017
PubMed
Summary

The persistent virome, including viruses like cytomegalovirus, significantly impacts immune aging. This review explores how these lifelong viral infections contribute to the aging of the immune system.

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