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Updated: Feb 25, 2026

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection
Bart Cortjens1, Rineke de Jong2, Judith G Bonsing2
1Paediatric Intensive Care, Emma Children's Hospital, Amsterdam, The Netherlands.
Abstract:
Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction. Viral load in the lower respiratory tract was not different between the two groups. We conclude that NETs form a relevant target for treatment of airway obstruction in severe RSV disease.
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