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Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction　- Monocyte to

Xue-Biao Wei1, Feng Chen2, Jie-Leng Huang1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academic of Medical Sciences.

Circulation Journal : Official Journal of the Japanese Circulation Society
|August 8, 2017
PubMed
Abstract

Insights

The monocyte to high-density lipoprotein cholesterol ratio (MHR) predicts death in infective endocarditis patients with normal heart function. Elevated MHR independently indicates higher risks of both in-hospital and long-term mortality.

Area of Science:

  • Cardiology
  • Inflammation markers
  • Clinical outcomes

Background:

  • The prognostic value of the monocyte to high-density lipoprotein cholesterol ratio (MHR) in infective endocarditis (IE) with normal left ventricular ejection fraction (LVEF) is not well-established.
  • MHR is an emerging inflammatory marker with potential clinical significance.

Purpose of the Study:

  • To investigate the prognostic value of MHR in patients diagnosed with IE and preserved LVEF.
  • To determine if MHR can predict in-hospital and long-term mortality in this specific patient cohort.

Main Methods:

  • A cohort of 698 patients with IE and normal LVEF were stratified into three groups based on MHR tertiles.
  • In-hospital death, major adverse clinical events (MACEs), and long-term survival were analyzed.
  • Receiver-operating characteristic (ROC) analysis and multiple regression models were employed.

Main Results:

  • In-hospital death occurred in 6.3% of patients, with rates increasing significantly across MHR tertiles (3.9% to 10.8%).
  • MHR demonstrated good predictive value for in-hospital death (AUC 0.670), comparable to C-reactive protein.
  • An MHR >21.3 was identified as an independent predictor of both in-hospital (OR 3.98) and long-term death (HR 2.29), even after adjusting for clinical confounders.

Conclusions:

  • Elevated MHR is significantly associated with increased in-hospital mortality in patients with IE and normal LVEF.
  • MHR serves as an independent predictor for both short-term and long-term adverse outcomes in this patient population.
  • The findings suggest MHR could be a valuable tool for risk stratification in IE patients with preserved cardiac function.
Keywords:
High-density lipoproteinInfective endocarditisMonocytesOutcomes

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