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Correlation study between gene and respiratory disease in children

Huaibin Liu1, Jie Min1, Haomiao Sun1

  • 1Department of Internal Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.

Experimental and Therapeutic Medicine
|August 8, 2017
PubMed

Insights

Elevated c-Jun N-terminal kinase 1 (JNK1) gene expression in children correlates with increased severity and occurrence of bronchitis. This finding offers a basis for diagnosing and treating pediatric bronchitis.

Area of Science:

  • Pediatric Respiratory Medicine
  • Molecular Biology
  • Immunology

Background:

  • Bronchitis is a common respiratory illness in children.
  • The role of specific genes, like c-Jun N-terminal kinase 1 (JNK1), in pediatric bronchitis pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between JNK1 gene expression and the incidence and severity of bronchitis in children.
  • To establish a potential diagnostic and therapeutic target for pediatric bronchitis.

Main Methods:

  • Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA), and western blot analysis were used to measure JNK1 gene and protein expression levels in blood samples.
  • A case-control study design compared children with bronchitis (observation group) to healthy children (control group).
  • Statistical analysis was performed using SPSS software to determine correlations.

Main Results:

  • JNK1 expression levels were significantly higher in children with bronchitis compared to healthy controls (P<0.05).
  • A positive correlation was observed between JNK1 expression levels and the severity of bronchitis in children.
  • JNK1 expression was notably higher in acute pediatric bronchitis cases than in chronic cases.

Conclusions:

  • JNK1 plays a significant role in promoting the development and exacerbation of bronchitis in children.
  • The findings provide a theoretical and experimental foundation for JNK1 as a biomarker and therapeutic target in pediatric bronchitis.

Keywords:
c-Jun N-terminal kinase 1diagnosis and treatment of bronchial asthma in children with respiratory diseases

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