Recent Progress in Biological Activities of Indole and Indole Alkaloids
Thokchom Prasanta Singh1, Okram Mukherjee Singh1
1Chemistry Department, Manipur University, Canchipur-795 003, Manipur, India.
Abstract:
The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks. This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.
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