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Odontomas in Peromyscus leucopus.

M P Finkel, L S Lombard, E F Staffeldt

    Journal of the National Cancer Institute
    |August 1, 1979
    PubMed
    Summary
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    Odontogenic tumors, specifically complex odontomas, were found in white-footed mice (Peromyscus leucopus). These benign growths occurred more frequently in younger male mice from a specific laboratory colony.

    Area of Science:

    • Veterinary Pathology
    • Mammalian Genetics
    • Oral Biology

    Background:

    • Established a colony of Peromyscus leucopus (white-footed mice) from wild-caught individuals 15 years ago.
    • The colony originated from animals trapped in the deciduous forest at Argonne National Laboratory, Illinois.
    • This study investigates spontaneous disease occurrence within this established mouse population.

    Purpose of the Study:

    • To survey and diagnose spontaneous odontogenic growths in a colony of Peromyscus leucopus.
    • To determine the incidence and characteristics of these growths within the study population.
    • To analyze potential associations between tumor occurrence and animal demographics (sex, age).

    Main Methods:

    • Conducted a roentgenographic survey of skeletons from 189 untreated Peromyscus leucopus mice.

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  • Mice included in the survey died naturally over a 13-month period.
  • Performed histopathologic examination to diagnose and classify identified growths.

    • Main Results:

    • Identified 48 odontogenic growths in 21 out of 189 mice.
    • Histopathologic diagnosis confirmed these growths as complex odontomas.
    • Incidence was higher in males than females and appeared associated with younger age.

    Conclusions:

    • Complex odontomas are spontaneous, benign tumors occurring in Peromyscus leucopus.
    • The incidence of these tumors is influenced by sex and age in this mouse colony.
    • Further research may elucidate specific genetic or environmental factors contributing to odontoma development.