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Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

Ahmet Arvas1, Haluk Çokuğraş1, Emel Gür1

  • 1Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.

Balkan Medical Journal
|August 8, 2017
PubMed

Insights

Pneumococcal conjugate vaccine (PCV13) implementation in healthy children resulted in a low carriage rate of Streptococcus pneumoniae. However, vaccine-type serotype colonization persisted, particularly in younger children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Nasopharyngeal carriage of Streptococcus pneumoniae is a key factor in disease transmission.
  • Pneumococcal conjugate vaccines (PCVs) aim to reduce carriage and disease burden.
  • PCV13 offers broader serotype coverage than the earlier PCV7 vaccine.

Purpose of the Study:

  • To assess the prevalence of Streptococcus pneumoniae nasopharyngeal carriage in young children vaccinated with PCV13.
  • To identify potential risk factors associated with pneumococcal carriage in this population.

Main Methods:

  • A cross-sectional study involving 150 healthy Turkish children aged 1 month to 6 years.
  • Serotyping of S. pneumoniae isolates to determine vaccine-type serotypes.
  • Evaluation of risk factors including recent respiratory infections, age, daycare attendance, and antibiotic use.

Main Results:

  • The overall carriage rate of S. pneumoniae was 14%.
  • Vaccine-type serotypes were found in 12.6% of fully PCV13-vaccinated children.
  • Carriage rates were highest in children under 24 months (76.2%).
  • No statistically significant risk factors for carriage were identified in multivariate analysis.
  • Most S. pneumoniae strains exhibited penicillin susceptibility with limited antimicrobial resistance.

Conclusions:

  • PCV13 implementation is associated with a reduced rate of pneumococcal carriage compared to PCV7.
  • Despite reduction, vaccine-type serotype colonization persists in PCV13-vaccinated children.
  • The findings highlight the ongoing need for surveillance and potential impact on transmission.
Abstract

Keywords:
Childrennasopharyngeal carriagepneumococcal conjugate vaccine Streptococcus pneumoniae.

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