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Updated: Feb 25, 2026

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
Published on: August 26, 2021
Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis
David Guenat1,2,3, François Hermetet4, Jean-Luc Prétet5,6
1EA3181, University Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, Rue Ambroise Paré, 25000 Besançon, France. david.guenat@univ-fcomte.fr.
Abstract:
Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and MVs are garnering increasing attention because of their ability to participate in cellular communication or transfer of bioactive molecules (mRNAs, microRNAs, DNA and proteins) between neighboring cancerous or normal cells, and to contribute to human cancer progression. Malignant traits can also be transferred from apoptotic cancer cells to phagocytizing cells, either professional or non-professional. In this review, we focus on Exos and ABs and their relationship with human papillomavirus (HPV)-associated tumor development. The potential implication of EVs as theranostic biomarkers is also addressed.
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