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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Aspergilasines A-D: Four Merocytochalasans with New Carbon Skeletons from Aspergillus flavipes QCS12
Guangzheng Wei1, Chunmei Chen1, Qingyi Tong1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
Abstract:
Aspergilasines A-D (1-4), four merocytochalasans with new skeletons, were isolated from the liquid culture broth of Aspergillus flavipes QCS12. Aspergilasine A (1) possesses a uniquely caged pentacyclo[7.2.0.14,11.02,7.05,10]dodecane skeleton with an unexpected cyclobutane ring that formed by the fusion of two epicoccine moieties via two [3 + 2] cycloadditions. Aspergilasines B-D (2-4) are key biosynthetic intermediates of epicochalasine B that fit well with our previous biosynthetic proposal.
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