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Related Concept Videos

Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

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Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Fungal Phylum Microsporidia01:28

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Candida auris: a worrisome, globally emerging pathogen.

Bhagyashri D Navalkele1, Sanjay Revankar2, Pranatharthi Chandrasekar3

  • 1a Infection Prevention and Antimicrobial Stewardship Fellow, Division of Infectious Diseases , Wayne State University/Detroit Medical Center , Detroit , MI , USA.

Expert Review of Anti-Infective Therapy
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Candida auris is a challenging, multidrug-resistant fungal pathogen causing hospital-acquired infections with high mortality. Early diagnosis and infection control are crucial for managing this emerging threat.

Keywords:
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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • Candida auris is a novel fungal pathogen causing serious hospital-acquired infections.
  • These infections are characterized by multidrug resistance and high mortality rates.
  • The rapid emergence of Candida auris presents a significant global health concern.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, and clinical presentation of Candida auris infections.
  • To discuss diagnostic challenges and current treatment strategies.
  • To highlight infection prevention and outbreak management measures.

Main Methods:

  • Literature review of epidemiology, pathogenesis, clinical presentation, diagnostics, and treatment.
  • Analysis of infection prevention and outbreak control strategies.
  • Expert commentary on the challenges posed by Candida auris.

Main Results:

  • Candida auris infections are hospital-acquired, multidrug-resistant, and have high mortality.
  • Early diagnosis and effective infection prevention are critical for patient outcomes.
  • Limited diagnostic availability and treatment options complicate management.

Conclusions:

  • The rapid emergence of hospital-onset Candida auris is a major concern.
  • Improved diagnostic methods and treatment options are urgently needed.
  • Further research is essential to understand and combat this difficult-to-treat pathogen.