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Related Experiment Video

Updated: Feb 25, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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IL-22: Scavenging beyond the barrier.

Sandip K Datta1

  • 1Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Science Immunology
|August 8, 2017
PubMed
Summary

Interleukin-22 (IL-22) triggers hemopexin production, which aids nutritional immunity by removing iron from Citrobacter rodentium during systemic infections.

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Area of Science:

  • Immunology
  • Microbiology
  • Nutritional Immunity

Background:

  • Systemic infections pose significant challenges to host defense.
  • Nutritional immunity is a critical host defense mechanism that restricts pathogen access to essential nutrients like iron.
  • Interleukin-22 (IL-22) is an important cytokine in mucosal immunity and host defense against bacterial pathogens.

Purpose of the Study:

  • To investigate the role of IL-22-induced hemopexin in nutritional immunity during systemic Citrobacter rodentium infection.
  • To determine how hemopexin contributes to iron scavenging and bacterial control.

Main Methods:

  • Induction of IL-22 and hemopexin in a mouse model of systemic infection.
  • Quantification of hemopexin levels and iron-binding capacity.
  • Assessment of bacterial load and host immune responses.

Main Results:

  • IL-22 significantly induced hemopexin expression during systemic infection.
  • Hemopexin effectively scavenged iron, limiting its availability to Citrobacter rodentium.
  • IL-22-induced hemopexin contributed to the control of bacterial dissemination and improved host survival.

Conclusions:

  • Hemopexin is a key mediator of IL-22-driven nutritional immunity.
  • Targeting hemopexin may represent a novel therapeutic strategy against systemic bacterial infections.

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