Related Experiment Video
Updated: Feb 25, 2026

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
Published on: September 8, 2023
Hyperbaric oxygen therapy for wound breakdown after oronasal fistula and cleft palate repair: four cases
C Lane Anzalone1, Cara C Cockerill1, Shelagh A Cofer1
1Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.
Insights
Hyperbaric oxygen (HBO) therapy shows promise for treating early surgical wound breakdown following cleft palate repair in children. This therapy helped reduce fistula size and improve wound healing in a small patient group.
Area of Science:
- Pediatric Surgery
- Wound Healing
- Oxygen Therapy
Background:
- Cleft palate repair can lead to oronasal fistulas and wound breakdown.
- Early intervention is crucial for successful surgical outcomes in pediatric patients.
Observation:
- Four pediatric patients with early surgical wound breakdown after cleft palate repair were treated with hyperbaric oxygen (HBO) therapy.
- HBO therapy was initiated promptly upon identification of oronasal fistulas.
Findings:
- All patients received 10-11 HBO treatments without adverse effects.
- Significant reduction in fistula size and development of granulation tissue at wound edges were observed.
- HBO therapy appeared to salvage portions of the surgical repair.
Implications:
- Hyperbaric oxygen therapy may be an effective adjunctive treatment for wound breakdown post-cleft palate repair.
- Early initiation of HBO therapy is associated with positive outcomes in pediatric wound healing.
- Further research is warranted to confirm these preliminary findings in larger cohorts.
Abstract:
We offer the first report of hyperbaric oxygen (HBO₂) therapy to treat early surgical wound breakdown after oronasal fistula and cleft palate repair in the pediatric population. We present four patients' experiences after undergoing HBO₂ therapy. HBO₂ was initiated as soon as an oronasal fistula was identified. Three of the children underwent 10 HBO₂ treatments with the fourth undergoing 11 treatments. There were no adverse effects during treatment; none of the patients required decompressive myringotomy. Follow-up shows portions of the repair have been salvaged by initiating HBO₂ at the first sign of fistula formation. In our case series, the fistulas all decreased in size over the course of treatment and demonstrated granulation tissue at the wound edges. Given the positive outcomes from our preliminary results, our results suggest concurrent usage of HBO₂ therapy for wound breakdown after cleft palate repair is an effective treatment option.
Related Concept Videos
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Cardiopulmonary Resuscitation II: ACLS Airway Management
Flail Chest-II
Assessment:
1. Clinical Evaluation:
History:
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen Delivering System III: Tracheostomy and T-piece
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...

