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Expired ipecac syrup efficacy.

P A Grbcich, P G Lacouture, J J Kresel

    Pediatrics
    |December 1, 1986
    PubMed
    Summary

    Expired ipecac syrup remains an effective emetic, even up to four years past its expiration date. This study found no significant difference in efficacy compared to unexpired syrup, offering valuable insights for emergency preparedness.

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    Area of Science:

    • Toxicology
    • Emergency Medicine
    • Pharmacology

    Background:

    • Ipecac syrup is a widely used emetic in poison management.
    • Concerns exist regarding the efficacy of expired ipecac syrup.
    • Limited data is available on the effectiveness of ipecac syrup beyond its expiration date.

    Purpose of the Study:

    • To evaluate the efficacy of expired ipecac syrup compared to unexpired ipecac syrup.
    • To determine if expiration date impacts the emetic properties of ipecac syrup.

    Main Methods:

    • A controlled prospective study was conducted at two regional poison control centers.
    • 200 patients received expired ipecac syrup, and 200 patients received unexpired ipecac syrup.
    • Patient and product characteristics were analyzed for statistical differences between groups.

    Main Results:

    • No statistical differences were observed in patient or product characteristics between the expired and unexpired ipecac syrup groups.
    • Emesis occurred in 100% of cases in both groups, with 90% vomiting after the first dose.
    • The mean time to emesis was comparable between groups (24.7 minutes for expired vs. 24.8 minutes for unexpired).

    Conclusions:

    • Expired ipecac syrup, up to 4 years postexpiration, is an effective emetic.
    • The duration of expiration did not alter the mean time to emesis.
    • Expired ipecac syrup can be considered a viable option when unexpired syrup is unavailable.

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