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Biphasic effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced stereotypy in rats

C Hara, A J Kastin

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1986
    PubMed

    Insights

    MIF-1 and Tyr-MIF-1 peptides modulate apomorphine-induced stereotypic behavior in rats. Their effects depend on the apomorphine dose, suggesting a link to central dopaminergic neuron activity.

    Area of Science:

    • Neuropharmacology
    • Behavioral Neuroscience

    Background:

    • Stereotypic behaviors are repetitive, invariant motor actions.
    • Apomorphine (APO) is a dopamine receptor agonist that induces stereotypic behavior.
    • MIF-1 and Tyr-MIF-1 are peptides with potential neuromodulatory roles.

    Purpose of the Study:

    • To investigate the effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced stereotypic behavior in rats.
    • To determine if the effects of MIF-1 and Tyr-MIF-1 are dose-dependent and influenced by apomorphine dosage.

    Main Methods:

    • Rats were administered various doses of apomorphine (0.08–2.0 mg/kg).
    • MIF-1 and Tyr-MIF-1 were administered at doses of 0.2, 0.5, 1.0, and 5.0 mg/kg.
    • Stereotypic behavior was quantified and analyzed in response to combined treatments.

    Main Results:

    • MIF-1 increased apomorphine-induced stereotypic behavior at 0.5 and 1.0 mg/kg APO doses.
    • MIF-1 decreased apomorphine-induced stereotypic behavior at a 2.0 mg/kg APO dose.
    • Tyr-MIF-1 exhibited a biphasic effect similar to MIF-1.

    Conclusions:

    • The effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced stereotypic behavior are dose-dependent.
    • These peptide effects appear to be modulated by the activity level of central dopaminergic neurons.

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