Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

11.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.8K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

39
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
39
Introduction to Metabolism01:30

Introduction to Metabolism

3.1K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
3.1K
Overview of Metabolism01:40

Overview of Metabolism

39.3K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
39.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.

Nature communications·2026
Same author

Dynamics of genetic and somatic trade-offs in ageing and mortality.

Nature·2026
Same author

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial.

Nature medicine·2026
Same author

Mitophagy in the pathogenesis and management of disease.

Cell research·2026
Same author

Genetic and dietary determinants of gut microbiome-bile acid interactions in the BXD genetic reference population.

Nature communications·2025
Same author

Genetic mapping of lifespan and mitochondrialstress response in C. elegans.

Research square·2025

Related Experiment Video

Updated: Feb 25, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.3K

Modulating NAD+ metabolism, from bench to bedside.

Elena Katsyuba1, Johan Auwerx2

  • 1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

The EMBO Journal
|August 9, 2017
PubMed
Summary

Nicotinamide adenine dinucleotide (NAD+) is vital for metabolic regulation and longevity. Boosting NAD+ levels can improve mitochondrial function, healthspan, and lifespan, offering benefits across various diseases.

Keywords:
agingmetabolic disordersneurodegenerationnicotinamide adenine dinucleotidepoly ADP‐ribose polymerase

More Related Videos

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR
09:05

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR

Published on: July 8, 2025

1.5K
Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
11:49

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Published on: November 17, 2013

9.6K

Related Experiment Videos

Last Updated: Feb 25, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.3K
Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR
09:05

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR

Published on: July 8, 2025

1.5K
Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
11:49

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Published on: November 17, 2013

9.6K

Area of Science:

  • Biochemistry
  • Metabolism
  • Molecular Biology

Background:

  • Nicotinamide adenine dinucleotide (NAD+) is a key oxidoreductase cofactor.
  • NAD+ is an essential cosubstrate for sirtuins, regulating metabolism and longevity.
  • Dysregulated NAD+ metabolism is linked to aging and diseases like metabolic, muscular, and neuronal disorders.

Purpose of the Study:

  • To review the fundamental biochemistry and metabolism of NAD+.
  • To discuss the potential health benefits of increasing NAD+ levels.
  • To explore the role of NAD+ in ameliorating mitochondrial homeostasis.

Main Methods:

  • Literature review of NAD+ biochemistry and metabolism.
  • Analysis of studies on NAD+ metabolism and its relation to aging and disease.
  • Discussion of strategies to boost NAD+ content.

Main Results:

  • NAD+ plays a crucial role beyond its cofactor function, acting as a substrate for regulatory proteins.
  • Increased NAD+ levels demonstrate therapeutic potential in a wide range of diseases.
  • Boosting NAD+ can positively impact mitochondrial function.

Conclusions:

  • NAD+ metabolism is critical for maintaining healthspan and lifespan.
  • Strategies to increase NAD+ levels hold promise for treating age-related and other diseases.
  • Enhancing NAD+ content is a viable approach to improve mitochondrial homeostasis and overall health.