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Magnetic Resonance Imaging of the Fibrotic Kidney

Glen R Morrell1, Jeff L Zhang2, Vivian S Lee2

  • 1Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah glen.morrell@hsc.utah.edu.

Journal of the American Society of Nephrology : JASN
|August 9, 2017
PubMed

Insights

Emerging magnetic resonance imaging (MRI) techniques offer new ways to assess kidney health and fibrosis noninvasively. While promising, these advanced MRI methods require further development for widespread clinical use in evaluating renal function.

Area of Science:

  • Medical Imaging
  • Nephrology
  • Biomedical Engineering

Background:

  • Traditional MRI primarily offers kidney anatomy.
  • New MRI techniques aim to assess kidney function and disease.
  • Fibrosis is a key indicator of kidney damage.

Purpose of the Study:

  • To review emerging MRI methods for kidney health assessment.
  • To outline the potential of these techniques in evaluating renal fibrosis.
  • To discuss current limitations and future directions for clinical implementation.

Main Methods:

  • Diffusion-weighted MRI
  • Renal blood oxygen level-dependent (BOLD) MRI
  • Renal MR elastography
  • Renal susceptibility imaging

Main Results:

  • These advanced MRI methods show promise for assessing kidney function and fibrosis.
  • Initial results indicate unique insights into renal health.
  • Significant limitations in accuracy and practicality currently hinder clinical adoption.

Conclusions:

  • Emerging MRI techniques hold potential for noninvasive renal fibrosis assessment.
  • Further research and development are crucial for clinical translation.
  • Overcoming current barriers is necessary to achieve reliable, image-based measures of kidney fibrosis.
Keywords:
MRIkidney imagingrenal fibrosis

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