Related Experiment Video

Updated: Feb 25, 2026

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

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Treatment of calmodulinopathy with verapamil

Gregory Webster1, Zachary J Schoppen1, Alfred L George2

  • 1Division of Cardiology, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

BMJ Case Reports
|August 9, 2017
PubMed

Insights

Genetic calmodulin variants cause severe heart rhythm disorders. This study explores using calcium channel blockers to treat calmodulinopathy, a condition linked to sudden death.

Area of Science:

  • Cardiology
  • Genetics
  • Pharmacology

Background:

  • Pathological variants in calmodulin genes are linked to severe cardiac conditions like sudden death.
  • Current treatments include beta-blockers and sodium-channel antagonists.
  • Calcium channel inactivation plays a crucial role in these disorders.
Keywords:
arrhythmiascardiovascular medicine

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