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Association between the TGF-β1 polymorphisms and chronic obstructive pulmonary disease: a meta-analysis
Ning Liao1, Hua Zhao1, Min-Li Chen1
1Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Bioscience Reports
|August 9, 2017
Summary
This meta-analysis found that the TGF-β1 gene
Area of Science:
- Genetics
- Pulmonology
- Molecular Biology
Background:
- Polymorphisms in the transforming growth factor-β1 (TGF-β1) gene are hypothesized to influence chronic obstructive pulmonary disease (COPD) risk.
- Previous studies on this association have yielded conflicting results, necessitating a comprehensive review.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between five common TGF-β1 gene polymorphisms and COPD risk.
- To clarify the role of specific TGF-β1 polymorphisms in COPD susceptibility across different ethnic groups.
Main Methods:
- A systematic meta-analysis of published case-control studies was performed.
- Data were sourced from major scientific databases including PubMed, Scopus, and Web of Science.
- Twelve studies encompassing 6749 participants were analyzed for associations between TGF-β1 polymorphisms (rs1982073, rs1800469, rs2241712, rs6957, rs2241718) and COPD risk.
Main Results:
- The TGF-β1 polymorphism rs1982073 (C allele) was significantly associated with a decreased risk of COPD in Caucasian populations (OR=0.79, P=0.038).
- No significant association was observed for rs1982073 in Asian populations (OR=0.95, P=0.741).
- The other four evaluated TGF-β1 polymorphisms (rs1800469, rs2241712, rs6957, rs2241718) showed no significant association with COPD risk in any population.
Conclusions:
- The C allele of the TGF-β1 polymorphism rs1982073 demonstrates a protective effect against COPD in Caucasians.
- This specific genetic association was not found in Asian populations.
- The evaluated polymorphisms rs1800469, rs2241712, rs6957, and rs2241718 are not significantly linked to COPD risk.
Keywords:
Chronic obstructive pulmonary diseasemeta-analysispolymorphismtransforming growth factor-β1More Related Videos
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