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Related Concept Videos

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

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Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Interstitial Granulomatous Dermatitis (IGD).

Tiberiu Tebeica1, Cristiana Voicu2, James W Patterson3

  • 1Dr Leventer Centre, 13-17 Sevastopol Street, Ste. 204, Bucharest 010991, Romania.

Open Access Macedonian Journal of Medical Sciences
|August 9, 2017
PubMed
Summary
This summary is machine-generated.

Interstitial granulomatous dermatitis (IGD) is a skin condition often mistaken for palisaded and neutrophilic granulomatous dermatitis (PNGD). Histological findings suggest they are distinct disorders despite similar clinical manifestations.

Keywords:
IGDmorphea likenecrobiosis lipoidicaplaqueprognostic valuetarget lesions

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Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Interstitial granulomatous dermatitis (IGD) is a rare skin condition.
  • It is often considered part of a spectrum with or synonymous with palisaded and neutrophilic granulomatous dermatitis (PNGD).
  • Both conditions are frequently associated with connective tissue diseases, particularly rheumatoid arthritis.

Purpose of the Study:

  • To present a case of interstitial granulomatous dermatitis.
  • To discuss the histological findings and differential diagnosis of IGD.
  • To explore the relationship between IGD and PNGD and their potential underlying conditions.

Main Methods:

  • Case report of a 42-year-old male with chronic skin changes.
  • Analysis of two skin biopsies showing dermal infiltrates of lymphocytes, histiocytes, and neutrophils.
  • Histopathological examination for granuloma formation, collagen degeneration, and mucin deposition.

Main Results:

  • Biopsies revealed a 'busy dermis' with interstitial, superficial, and deep infiltrates.
  • Findings included poorly formed granulomas with giant cells and collagen degeneration.
  • No mucin deposition or frank collagen necrobiosis was observed.
  • Clinical and histological findings supported a diagnosis of interstitial granulomatous dermatitis.

Conclusions:

  • Interstitial granulomatous dermatitis and palisaded and neutrophilic granulomatous dermatitis are distinct entities.
  • While often linked to autoimmune disorders, IGD can occur in patients with metabolic diseases, lymphoproliferative disorders, or malignancies.
  • Further research is needed to fully understand the pathogenesis and classification of these granulomatous dermatitides.