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Hope for CKD-MBD Patients: New Diagnostic Approaches for Better Treatment of CKD-MBD

Berthold Hocher1,2,3,4, Andreas Pasch5

  • 1Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Germany.

Kidney Diseases (Basel, Switzerland)
|August 9, 2017
PubMed
Abstract

Insights

New diagnostic tools offer hope for personalized treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). These advancements in measuring parathyroid hormone and calcification risk can improve patient outcomes.

Area of Science:

  • Nephrology
  • Endocrinology
  • Biochemistry

Background:

  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) is associated with high morbidity and mortality.
  • Therapeutic strategies for CKD-MBD have seen limited progress due to a lack of predictive diagnostic tools.
  • Personalized treatment approaches are needed for effective CKD-MBD management.

Purpose of the Study:

  • To review recent advancements in diagnosing calcium and phosphate metabolism disturbances in CKD-MBD.
  • To highlight new diagnostic tools for predicting patient outcomes.
  • To discuss the potential for personalized therapy in CKD-MBD.

Main Methods:

  • Review of current diagnostic methods for CKD-MBD.
  • Focus on measuring biologically active nonoxidized parathyroid hormone (PTH).
  • Assessment of tools for predicting vascular calcification risk.

Main Results:

  • Recent progress in diagnosing calcium and phosphate metabolism disorders in CKD-MBD patients.
  • Identification of methods to measure active nonoxidized PTH.
  • Evaluation of tools to assess calcification likelihood.

Conclusions:

  • New diagnostic tools show promise for CKD-MBD management.
  • Personalized therapy for CKD-MBD is becoming more attainable.
  • Improved diagnostic capabilities may lead to better patient outcomes.
Keywords:
BiomarkerCalcification propensityChronic kidney disease-mineral and bone disorderMorbidityMortalityNonoxidized parathyroid hormoneT50 test

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